The Latest | Israeli airstrikes on Rafah kill at least 22 people, Palestinian health officials say

Israeli airstrikes on the southern Gaza city of Rafah have killed at least 22 people, including six women and five children, Palestinian health officials said. One of the children killed in the strikes overnight into Monday was just 5 days old.

Israel has regularly carried out airstrikes on Rafah since the start of the war and has threatened to send in ground troops, saying Rafah is the last major Hamas stronghold in the coastal enclave. Over a million Palestinians have sought refuge in the city on the Egyptian border. The United States and others have urged Israel not to invade, fearing a humanitarian catastrophe.

U.S. Secretary of State Antony Blinken on Monday begins his seventh diplomatic mission to the Middle East since the Israel-Hamas war began more than six months ago.

Blinken’s visit — which includes a little more than a day in Saudi Arabia before stops in Jordan and Israel on Tuesday and Wednesday — comes amid renewed concerns about the conflict spreading in the Middle East and with once-promising prospects for Israeli-Saudi rapprochement effectively on hold as Israel refuses to consider one of the Saudis’ main conditions for normalized relations: the creation of a Palestinian state.

The Israel-Hamas war was sparked by the unprecedented Oct. 7 raid into southern Israel in which militants killed around 1,200 people, mostly civilians, and abducted around 250 hostages. Israel says the militants are still holding around 100 hostages and the remains of more than 30 others.

The war has killed more than 34,000 Palestinians, according to local health officials, around two-thirds of them children and women.

Currently:

— Hamas is reviewing an Israeli proposal for a cease-fire in Gaza, as a planned Rafah offensive looms

— Biden and Netanyahu speak as pressure is on Israel over planned Rafah invasion and cease-fire talks

— Blinken is back in the Middle East this week. He has his work cut out for him

— Top French diplomat arrives in Lebanon in attempt to broker a halt to Hezbollah-Israel clashes

— Arrests roil US campuses nationwide ahead of graduation as protesters demand Israel ties be cut

— AP’s full coverage of Israel-Hamas war

Here is the latest:

ISRAELI AIRSTRIKES KILL AT LEAST 22 PEOPLE IN RAFAH, PALESTINIAN OFFICIALS SAY

RAFAH, Gaza Strip — Israeli airstrikes on the southern Gaza city of Rafah have killed at least 22 people, including six women and five children, Palestinian health officials say. One of the children killed in the strikes overnight into Monday was just 5 days old.

Israel has regularly carried out airstrikes on Rafah since the start of the war and has threatened to send in ground troops, saying Rafah is the last major Hamas stronghold in the coastal enclave. Over a million Palestinians have sought refuge in the city on the Egyptian border. The United States and others have urged Israel not to invade, fearing a humanitarian catastrophe.

The overnight strikes hit three family homes. The first killed 11 people, including four siblings aged 9 to 27, according to records at the Abu Yousef al-Najjar Hospital, where the bodies were taken. The second strike killed eight people, including a 33-year-old father and his 5-day-old boy, according to hospital records. The third strike killed three siblings, aged 23, 19 and 12. An Associated Press reporter saw the bodies at the hospital.

Israel blames the high civilian death toll on Hamas because the militants fight in densely populated areas. But the military rarely accounts for individual strikes, which often kill women and children.

BLINKEN BEGINS HIS SEVENTH DIPLOMATIC MISSION TO THE MIDDLE EAST SINCE WAR BEGAN

RIYADH, Saudi Arabia — U.S. Secretary of State Antony Blinken on Monday begins his seventh diplomatic mission to the Middle East since the Israel-Hamas war began more than six months ago.

Just ahead of Blinken’s visit — which includes a little more than a day in Saudi Arabia before stops in Jordan and Israel on Tuesday and Wednesday — President Joe Biden spoke by phone Sunday with Israeli Prime Minister Benjamin Netanyahu.

Blinken’s trip comes amid renewed concerns about the conflict spreading in the Middle East and with once-promising prospects for Israeli-Saudi rapprochement effectively on hold as Israel refuses to consider one of the Saudis’ main conditions for normalized relations: the creation of a Palestinian state.

The conflict has fueled mass protests around the world that have spread to American college campuses. U.S. support for Israel, particularly arms transfers, has come under particular criticism, something the administration is keenly aware poses potential problems for Biden in an election year.

BIDEN SPEAKS WITH NETANYAHU AGAIN AS PRESSURE BUILDS FOR CEASE-FIRE

TEL AVIV, Israel — U.S. President Joe Biden has again spoken with Israeli Prime Minister Benjamin Netanyahu, the White House said Sunday, as pressure builds on Israel and Hamas to reach a deal that would free some Israeli hostages and bring a cease-fire in the nearly seven-month-long war in Gaza.

The White House said that Biden reiterated his “clear position” as Israel plans to invade Gaza’s southernmost city of Rafah despite global concern for more than 1 million Palestinians sheltering there. The U.S. opposes the invasion on humanitarian grounds, straining relations between the allies. Israel is among the countries U.S. Secretary of State Antony Blinken will visit as he returns to the Middle East on Monday.

Biden also stressed that progress in delivery of humanitarian aid to Gaza be “sustained and enhanced,” according to the statement. The call lasted just under an hour, and they agreed the onus remains on Hamas to accept the latest offer in negotiations, according to a U.S. official who spoke on condition of anonymity because the official wasn’t authorized to comment publicly.

There was no comment from Netanyahu’s office.